Golpar Gholizadeh Shirdarreh - Department of Clinical Pharmacy, Cardiovascular Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Gohar Eslami - Department of Clinical Pharmacy, Cardiovascular Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Aria Soleimani - Department of Anaesthesiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Ebrahim Salehifar - Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Resistance to antibiotics, including aminoglycosides  (AMG) is one of the problems associated with inappropriate administration of broad-spectrum antibiotics. Objectives: This study aimed to assess the clinical features of aminoglycosides consumption based on the Defined Daily Dose (DDD) index in open heart surgery. Methods: This study was done on ۲۶۸ patients who underwent heart surgery during ۲۰۱۵ and ۲۰۱۶. Clinical and demographic characteristics, laboratory data, and aminoglycoside-related data such as dose and the total duration of administration were collected through a questionnaire designed by the authors. The patients’ DDD/۱۰۰ bed-days were calculated, too. Results: Out of ۲۶۸ patients, ۱۷۰ patients (۶۳.۴%) were male. The Mean±SD age of the patients was ۶۰.۶۵±۱۰.۷۱ years and the Mean±SD duration of hospitalization was ۱۲.۱۹±۷.۰۲ days. Ischemic heart disease was the most prevalent cause of hospitalization. The Mean duration of receiving aminoglycosides was ۳.۶۱ days. In ۱۳۴ patients (۵۰%), creatinine clearance was less than ۶۰ mL/min during aminoglycosides administration. In ۲۵ patients (۹.۳۲%), a ۵۰% increase in serum creatinine during receiving aminoglycosides was observed. Creatinine clearance had not been calculated for any patient. Conclusion: In this study, monitoring the side effects of aminoglycosides and the serum concentration was not routinely performed. Dose adjustment of aminoglycosides based on renal function test was not considered in a large number of patients and as a result, the dose was inappropriate in many patients. Therefore, it is recommended that the guidelines of drug usage were followed and the patients were monitored more closely for side effects.

Intensive Care Units (ICU), Rational use, Cardiac surgery, Microbial resistance, Prophylactic antibiotic, Aminoglycosides, Defined Daily Dose (DDD)