Mahkameh Soltani - Pharmaceutical sciences research center,Hemglobinopathy Institute,Mazandaran Univesrsity of Medical Sciences,Sari Iran
Ramin Ataee - Pharmaceutical sciences research center,Hemglobinopathy Institute,Mazandaran Univesrsity of Medical Sciences,Sari Iran

Peraxisome prolifrator-activated receptors (PPARs) are a group of nuclear receptors comprising three isoforms termed alpha, beta/delta and gamma. PPARs can modulate metabolic processes especially fatty acid (FA) metabolisms via exerting transcriptional control on activating genes involved in fuel utilization. Thus, they can exert positive role in controlling chronic diseases such as diabetes. As development of diabetes leads to functional and structural alterations at the myocardium termed diabetic cardiomyopathy (DCM), metabolic controller seems to be able to affect on cardiomyocytes. Herein, the role of PPARα, and PPARδ, is emerged and compared. This minireview discusses about these receptors in diabetes.

Peraxisome prolifrator-activated receptors (PPARs), metabolic processes, Fatty acid (FA), diabetic cardiomyopathy (DCM), PPARα, PPARδ