Investigation of the effect of ۸ weeks of high-intensity interval training and berberine supplementation on some echocardiography and electrocardiogram indices following myocardial ischemia-reperfusion in rats
عنوان مقاله: Investigation of the effect of ۸ weeks of high-intensity interval training and berberine supplementation on some echocardiography and electrocardiogram indices following myocardial ischemia-reperfusion in rats
شناسه ملی مقاله: JR_RYA-18-4_011
منتشر شده در در سال 1401
شناسه ملی مقاله: JR_RYA-18-4_011
منتشر شده در در سال 1401
مشخصات نویسندگان مقاله:
Parisa Banaei - PhD in Sport Physiology, Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran
Farzad Nazem - Professor, Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran
Mehrnoosh Sedighi - PhD in Cardiovascular Physiology, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran
خلاصه مقاله:
Parisa Banaei - PhD in Sport Physiology, Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran
Farzad Nazem - Professor, Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran
Mehrnoosh Sedighi - PhD in Cardiovascular Physiology, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran
BACKGROUND: Myocardial ischemia leads to left ventricular (LV) dysfunction and cardiac arrhythmia. The present research was conducted with the aim to explore echocardiography changes and electrocardiogram parameters of the hearts of rats with ischemia-reperfusion injury (IRI).METHODS: The study subjects included ۵۰ male Wistar rats) ۸-۱۰ weeks), which were divided into ۵ groups (۱: trained, ۲: supplemented, ۳: combined (training and supplementation), ۴: sham, and ۵: control). High-intensity interval training (HIIT) was performed for ۸ weeks, ۵ sessions per week. Rats belonging to groups ۲ and ۳ received ۱۰ mg/kg berberine. Finally, after ۴۸ hours, electrocardiogram and echocardiography were performed on all rats. Moreover, myocardial ischemia was performed by descending coronary artery ligation for ۳۰ minutes.RESULTS: There were significant differences between the ۵ groups in terms of the volumes and dimensions of LV end-systolic dimension (LVSD), LV end-diastolic dimension (LVDD), fractional shortening cardiac output, ejection fraction (EF), stroke volume (SV), ventricular tachycardia (VT), and ventricular ectopic beats (VEBs) episodes, duration of VTs, and ECG parameters (P ≤ ۰.۰۵).CONCLUSION: Berberine supplementation and HIIT, as preconditioning agents, can possibly prevent the elevation of EF and fractional shortening, the reduction of cardiac output and SV, and arrhythmia improvement after myocardial IRI. Finally, these changes result in increased LV function and decreased mortality in rats with myocardial IRI.
کلمات کلیدی: Berberine, Echocardiography, Electrocardiography, High-Intensity Interval Training, Infarction
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1873062/