Atena Shiva - Associate Professor, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Shahin Arab - PhD in Clinical Biochemistry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Maziar Khatami - .Department of Periodontics,Dental Research Center,Faculty of Dentistry,Mazandaran University of Medical Sciences,Sari,Iran
Nika Rezaeikalantari - Dental Research Center, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
Rezvan Yazdian - Department of Molecular and Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Parastoo Namdar - Department of Orthodontics, Dental Research Center, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran

Background: Developing cell-based therapeutic methods for differentiating various stem cells into dental tissues could be a revolutionary step toward using cell therapy for dental diseases. In the present study, we systematically reviewed the literature to determine the efficiency of stem cells in treating various dental diseases. Methods: Using the search words “stem cell” and “dental disease” as well as all their equivalents and similar terms, we performed a literature search in September ۲۰۲۰ in the electronic databases: PubMed, Scopus, Science Direct, Web of Science, Embase, Ovid, and Google Scholar. The investigation was limited to clinical trials written in the English language. Results: Overall, ۲۲ articles with ۴۰۰ study patients were found and used for qualitative data synthesis. Findings showed that various stem cells with different origins can be used for cell therapy of various dental diseases such as pulp necrosis, traumatic dental injuries, maxillofacial bony defects, impacted third molars, etc. Conclusion: Stem cell therapy is an efficient method for treating dental diseases. It can regenerate whole dental pulp and may be useful for treating tooth injuries due to trauma.

Stem cell, Bone regeneration, Dental disease, Differentiation, Regeneration