Maryam Karkhane - Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abdolrazagh Marzban - Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Hamed Esmaeil Lashgarian - Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
Mohammad Reza Zali - Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Although standard treatments are nearly life-saving in hepatitis C patients, all patients equalldon’t respond to such medications. To achieve an efficient therapeutic response in all patients, medications should individually alter based on genetic factor variations. Hence, having more detailed knowledge of the affective factors on the disease promotion could help us to organize an appropriate regime to treat HCV patients. In order to review recent studies on HCV-related treatments, the data was collected from the clinical and molecular studies published during the last ۱۵ years in electronic databases such as PubMed, Google Scholar, Medline, Scopus and Web of Sciences. Thus, this literature reviews the recent clinical studies with the genetic-based aspects, especially those factors affecting the etiopathological and histological feature of hepatitis C, diagnostic genetic and viral affecting criteria as well as some effective treatment strategies.

Hepatitis C virus, Genetic Host Factors, Sustained Virologic Response