Hossein-Ali Ebrahimi - Neurology Research Center, Department of Neurology, Kerman University of Medical Sciences, Kerman, Iran
Mohammad-Hasan Larizadeh - Neurology Research Center, Department of Neurology, Kerman University of Medical Sciences, Kerman, Iran
Mohammad Saba - Department of Radiology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Abdollah Jafarzadeh - Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Background: Multiple sclerosis (MS) as a complex neurological abnormality is marked with loss of myelin and axons due to chronic inflammatory and autoimmune responses. The modulatory properties of the low dose radiation (LDR) on inflammatory and immune responses have well known.Objective: The current research aimed to assess the impacts of LDR on the disability in patients suffering from MS.Material and Methods: This experimental pilot study was done on ۱۰ patients with secondary progressive multiple sclerosis (SPMS). After magnetic resonance imaging, the SPMS patients were treated by LDR at a daily dose of ۲ Gray for ۵ consecutive days (totally ۱۰ Gray dose) using a linear accelerator. The extent of the disability was evaluated one week after the completion of radiotherapy using expanded disability status scale (EDSS).Results: After receiving radiotherapy, the patients had a feeling of wellbeing of some sort. The mean of EDSS was significantly reduced after radiotherapy compared with before irradiation (۷.۴±۰.۴۵ vs ۶.۳۵±۱.۱۸; P<۰.۰۱۷). EDSS more decreased in younger SPMS patients (P=۰.۰۰۰۱), and in the women after LDR (P=۰.۰۲۷). Conclusion: Radiotherapy can reduce fatigue and EDSS in patients with SPMS. The age and gender of patients may influence the LDR efficacy.

Human, autoimmune disease, Multiple Sclerosis, Radiotherapy, Disability