S Amiri - Department of Medical Physics and Biomedical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
MM Movahedi - Department of Medical Physics and Biomedical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
K Kazemi - Department of Electrical and Electronics Engineering, Shiraz University of Technology, Shiraz, Iran
H Parsaei - Department of Medical Physics and Biomedical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Background: Brain tissue segmentation for delineation of ۳D anatomical structures from magnetic resonance (MR) images can be used for neuro-degenerative disorders, characterizing morphological differences between subjects based on volumetric analysis of gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF), but only if the obtained segmentation results are correct. Due to image artifacts such as noise, low contrast and intensity non-uniformity, there are some classification errors in the results of image segmentation.Objective: An automated algorithm based on multi-layer perceptron neural networks (MLPNN) is presented for segmenting MR images. The system is to identify two tissues of WM and GM in human brain ۲D structural MR images. A given ۲D image is processed to enhance image intensity and to remove extra cerebral tissue. Thereafter, each pixel of the image under study is represented using ۱۳ features (۸ statistical and ۵ non- statistical features) and is classified using a MLPNN into one of the three classes WM and GM or unknown.Results: The developed MR image segmentation algorithm was evaluated using ۲۰ real images. Training using only one image, the system showed robust performance when tested using the remaining ۱۹ images. The average Jaccard similarity index and Dice similarity metric for the GM and WM tissues were estimated to be ۷۵.۷ %, ۸۶.۰% for GM, and ۶۷.۸% and ۸۰.۷%for WM, respectively.Conclusion: The obtained performances are encouraging and show that the presented method may assist with segmentation of ۲D MR images especially where categorizing WM and GM is of interest.

Image segmentation, Artificial neural networks, Multi-layer perceptron