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Investigating the effect of carbendazim poison on elastase enzyme using Thermal Stability, FTIR and docking methods

عنوان مقاله: Investigating the effect of carbendazim poison on elastase enzyme using Thermal Stability, FTIR and docking methods
شناسه ملی مقاله: ENGCONGE04_002
منتشر شده در چهارمین کنفرانس بین المللی یافته های پژوهشی در علوم پایه و علوم مهندسی در سال 1402
مشخصات نویسندگان مقاله:

Mahbubeh Abdellahi - Student , Department of Biology Biology, Shahrekord University University, ShahrekordShahrekord, Iran
Sadegh Farhadian - Assistant Professor,Department of Biology Biology, Shahrekord University University, ShahrekordShahrekord, Iran
Behzad Shareghi - Full Profesor, Department of Biology Biology, Shahrekord University University, ShahrekordShahrekord, Iran

خلاصه مقاله:
Carbendazim is a systemic fungicide with the molecular formula C۹H۹N۳O۲. This type of fungicide is used to control and treat diseases caused by fungi on vegetables, fruits and various types of plants. Carbendazim causes infection in humans through routes such as mouth, skin, and inhalation and it is considered an environmental pollutant .In fact, the components resulting from the decomposition of this compound, for example, amino bezimidazole, limit cell division by acting on microtubules.And as a result, reproductive damage or fertility disorders are created. Elastase is a glycoprotein enzyme that belongs to the serine proteases family, which breaks down peptide bonds. It is secreted from the endocrine gland of the pancreas and is one of the proteases that catalyze the breakdown of elastin protein, a component of connective tissue.In a recent study, the effect of carbendazim on elastase enzyme was investigated using FTIR and TM spectroscopy. The results showed that carbendazim makes the elastase enzyme more unstable and also affects its secondary structure.

کلمات کلیدی:
Carbendazim, fungicide, Elastase, spectroscopy

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1897550/