امیر حسین دارابی - Department of Epidemiology, The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
مرجان زمانی - Department of Immunology and Allergy, The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
اله کرم اخلاقی - Department of Otorhinolaryngology and Head and Neck Surgery, The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
مرضیه محمودی - Department of Biostatistics and Epidemiology, School of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran
علی موحد - Department of Biochemistry, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
رضا کبودخانی - Department of Otorhinolaryngology and Head and Neck Surgery, Shiraz University of Medical Sciences, Shiraz, Iran
امیر گره - Department of Immunology and Allergy, The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
زهرا محمدی - Department of Immunology and Allergy, The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
شکراله فرخی - Department of Immunology and Allergy, The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran

Background & Objective: Chronic rhinosinusitis (CRS) is a high prevalent disease throughout the world. The aim of this study was to investigate the epidemiological and clinical characteristics of the CRS patients. Materials & Methods: A total of ۲۴۱ CRS patients aged ۱۵-۷۰ years were recruited. The prevalence of allergic diseases and its association with CRS, disease severity, and quality of life (QoL) were assessed using GA۲LEN and SNOT-۲۲ questionnaires, respectively. Patients' clinical diagnoses and allergic comorbidities were evaluated using paranasal sinus computed tomography (CT), nasal endoscopy, and paraclinical tests (smell identification test, fractional exhaled nitric oxide (FeNO), skin prick test (SPT), pulmonary function test (PFT)). Results: The mean (±SD) age of all participants was ۴۰.۱±۱۱.۱ years, with a gender distribution of ۵۶% male and ۴۴% female. Nasal polyps (NP) were diagnosed in ۴۲.۴% of patients. The total mean SNOT-۲۲ scores and the mean scores of the nasal symptoms category were significantly higher in CRS patients with NP (CRSwNP) compared to CRS without NP (CRSsNP) (OR = ۲.۳, ۹۵%CI = ۹.۶–۰.۵۵, P = ۰.۰۲۸). Furthermore, there was a significant association between CRSwNP and persistent allergic rhinitis comorbidity (P = ۰.۰۰۶). Finally, a significant association was found between CRSwNP and severe SPT reactivity to Dermatophagoides farina and date palm pollen (P = ۰.۰۴ and P < ۰.۰۰۱, respectively). Conclusion: This study suggests that higher SNOT-۲۲ scores may impact QoL in CRSwNP patients. Additionally, a significant association was found between CRS and respiratory allergic diseases.

Chronic rhinosinusitis, Allergic diseases, EPOS۲۰۲۰, GA۲LEN, SNOT-۲۲