Elham Adibfar - Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
Seyed Ali Hoseini - Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
Omidreza Salehi - Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
Fatemeh Farkhaie - Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
Parvin Shah Hosseini - Doctor of Veterinary Medicine

Introduction: Diabetes mellitus is one of the most common non-communicable and chronic diseases. The present study aimed to review the lipid lowering effects of aqueous saffron extract in diabetic rats. Methods: Sixty diabetic rats with fasting blood glucose of over ۳۰۰ mg/dl were selected as sample and divided in two groups of saffron extract and control. Group of saffron extract received ۲۵ mg/kg daily aqueous saffron extract peritoneally for ۴ weeks. Lipid profile was measured by enzymatic method with zist shimi commercial kits provided by yasa teb Company. For statistical analysis of data, Kalmogorov- Smirnov test and paired sample and independent sample t- tests (p≤۰.۰۵) were used. Results: Findings showed that ۴ weeks saffron extract induces significant reduction in LDL, VLDL, TG and Cho of diabetic rats (p=۰.۰۰۱); nevertheless, it has no significant effect on HDL (p=۰.۰۷). Conclusion: It is concluded that ۴ weeks aqueous saffron extract has lipid lowering effect in diabetic rats.

Saffron, Lipid Profile, Diabetes