Issam Mohammad Shakir - College of Science, Chemistry Department, University of Baghdad, Republic of Iraq
Bakr Sadiq Mohammed - College of Science, Chemistry Department, University of Baghdad, Republic of Iraq
Nagham Shakir Turkey - College of Science, Chemistry Department, University of Baghdad, Republic of Iraq

An innovative and effective method for continuous flow injection analysis (CFIA) was developed and included in the NAG_۴SX۳_۳D Analyzer. The primary objective of this approach was to quantify the concentration of loratadine. This study presents a methodology for the quantification of loratadine, an antihistaminic medication, in pharmaceutical formulations. The samples are analyzed using the NAG_۴SX۳_۳D Analyzer, which is a device that combines optical, chemical, electronic, and detection capabilities. The analyzer operates by receiving a cumulative signal, eliminating the need for amplification. The total distance travelled is ۷۶۰ mm in relation to the variable YZ -mV during a period of time represented by t seconds (measured in mm). The selection was made based on the accurate computation of the energy transducer profile. The relative standard deviations for loratadine are ۰.۰۹% at a concentration of ۵ m.M and ۰.۱% at a concentration of ۸ m.M for n = ۶. The limit of detection (LOD) and limit of quantification were found to be ۶۱۱.۰۷۶ ng and ۱۲۹ μg, respectively, using a stepwise dilution of the lowest concentration on the calibration curve with a sample size of n = ۱۳. The linear range has a correlation coefficient (r) of ۰.۹۹۸۹, indicating a strong positive relationship. Additionally, the linearity of this range is measured at ۹۹.۷۹% (R۲) and recovery is not less than ۹۶.۵۸%, suggesting a high degree of conformity to a linear model. A comparative analysis was conducted between the outcomes of the suggested methodology and the existing UV-spectrophotometric approach, specifically at a wavelength of ۲۷۵nm, revealing similar findings.

Loratadine, Continuous flow Injection analysis (CFIA), NAG-۴SX۳-۳D analyzer