Payam Sharifan - Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hamideh Ghazizadeh - Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Susan Darroudi - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
Alireza Ghodsi - Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Sara Saffar Soflaei - ۳ International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
Davoud Tanbacoochi - Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Reza Fazl Mashhadi - Department of Nutritions, Varastegan Institute for Medical Sciences, Mashhad, Iran
Mohammad Amin Mohammadi - Department of Nutritions, Varastegan Institute for Medical Sciences, Mashhad, Iran
Ali Ebrahimi dabagh - Department of Nutritions, Varastegan Institute for Medical Sciences, Mashhad, Iran
Sara Moazedi - Department of Nutritions, Varastegan Institute for Medical Sciences, Mashhad, Iran
Maryam Mohammadi Bajgiran - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
Gordon Ferns - Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN۱ ۹PH,
Habibollah Esmaily - Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
Majid Ghayour-Mobarhan - Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Vitamin D deficiency is a worldwide condition, which has been linked to a variety of health-related issues. Vitamin D can be beneficial to cardiovascular patients and those suffering from depression and anxiety, based on Survey of Ultraviolet Intake by Nutritional Approach (SUVINA study), ,showing the potential effects of vitamin D-fortified dairy products on anxiety, depression, and stress in subjects with cardiovascular disease (CVD) risk factors. Methods: It was a quadruple-blind randomized controlled trial. Individuals were randomly allocated to one of four groups: fortified low-fat milk (FM), non-fortified low-fat milk (NFM), fortified low-fat yogurt (FY), and non-fortified low-fat yogurt (NFY). FM and FY groups were fortified with ۱۵۰۰ IU nano-encapsulated vitamin D۳. Anthropometric parameters as well as depression, anxiety, and stress scores were measured at baseline and after a ten-week trial in Mashhad, Iran. Results: Totally, ۲۸۹ participants (۱۴۳ men, ۱۴۶ women) with a mean age of ۴۱.۸۶±۷.۸۱years were enrolled in the study. There was no statistical difference between the scores of depression, anxiety, and stress in participants with and without CVD risk factors (P>۰.۰۵).  No statistical difference was found in the subgroup analysis based on milk and yogurt consumption. Conclusions: Fortified low-fat milk containing ۱,۵۰۰ IU of vitamin D has no impact on improving depression, anxiety, and stress during ten weeks. However, further studies with higher vitamin D doses for a longer duration are recommended.

Vitamin D, Fortification, Anxiety, Depression