Maryam Esfahani
Mohammad Taghi Goodarzi

ANGPTL۸, a new hormone, is regarded as a novel target for type-۲ diabetes and associated metabolic disorder. Nutritional state and hormonal factors are involved in the regulation of ANGPTL-۸ expression. This protein is associated with some myokines or adipokines. Several studies confirmed the function of ANGPTL-۸ in glucose metabolism and diabetes complications; however, there are opposite results. The accurate function of ANGPTL-۸ in T۲D remains unclear. Further strictly controlled studies including measuring methods, nutritional state, diagnostic criteria of overweight/obesity, age, and ethnicity may help to resolve discrepancies. In addition, more studies are demanded to clarify the potential role of ANGPTL-۸ in humans, a cause or an effect of this protein in association with insulin resistance, the regulatory mechanism of ANGPTL-۸ expression, and the association of ANGPTL۸ with other adipokines or myokines. In this mini review, we described various roles of ANGPTL-۸ in diabetes.