Sabereh Ahmadzadeh - School of Pharmacy, Shahid Sadoughi University of Medical science, Yazd, Iran
Mehrnoosh Sedighi - Lorestan University of Medical Sciences, Khorramabad, Iran
Amin Torkashvand - Malayer Faculty of Nursery, Hamedan University of Medical Sciences and Health Services, Malayer, Hamedan, Iran
Pejman Hashemzadeh - Department of Medical Biotechnology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Fateme Shafiei - Cardiovascular Research center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran
Mohammad Torkashvand - Fouman Faculty of Engineering, College of Engineering, University of Tehran, Fouman, Iran
Atefeh Hasan-Zadeh - Fouman Faculty of Engineering, College of Engineering, University of Tehran, Fouman, Iran

The SARS-COV-۲ virus is the cause of the ۲۰۲۰ pandemic that has infected and killed millions worldwide. While the upper respiratory tract cells are the primary targets of COVID-۱۹, the virus can infiltrate other tissues and organs, leading to potentially serious complications. The new coronavirus primarily affects angiotensin II receptor and cytokine pathways, which can result in acute pulmonary inflammation, pulmonary edema, acute respiratory distress syndrome, vascular endothelial dysfunction, pulmonary embolism in the lungs, and cardiomyopathy, arrhythmia, heart failure, and intravenous thrombosis in the heart. COVID-۱۹ infection can be associated with gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain. Also, reports of mild and transient liver damage, polyneuropathy, encephalitis, stroke, acute renal failure, hypocortisolism, and damage to the hypothalamus and pituitary system are available. COVID-۱۹ can also be associated with skin symptoms such as rash, urticaria, maculopapular lesions, and vascular lesions such as chill blain, petechiae purpura, and scalpopathy. This narrative review evaluates the pathogenesis of novel coronavirus on body organs based on relevant published papers and reference books.

COVID-۱۹, Pathogenesis, SARS-COV-۲ Infection, Viral infections