The Role of the Gray Wolf in Rabies Transmission in Iran and Preliminary Assessment of an Oral Rabies Vaccine in this Animal

Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JMMI-5-3_005

تاریخ نمایه سازی: 29 بهمن 1402

Abstract:

Introduction: In Iran, ۹۵% of animal bites are attributed to domestic dogs and cats, while one-third of rabies victims are from wildlife. The wolf is one of the primary vectors of wildlife in the country. This study was aimed to assess the impact of wildlife on rabies transmission and to evaluate the efficacy of an oral rabies vaccine (ORV) in the gray wolf (Canis lupus pallipes). Methods: We studied the incidence of wolf attacks by analyzing a ۱۰-year period of data (۲۰۰۰ to ۲۰۰۹) available in the Ministry of Health and Medical Education, the Veterinary Organization and Pasteur Institute of Iran. In the next step, five captive gray wolves were fed by Raboral V-RG® vaccine baits (Merial®, part of Boehringer Ingelheim, Germany) and monitored for rabies neutralizing antibodies over ۲۰ months by rapid fluorescent focus inhibition test (RFFIT). Results: Our analysis showed that ۵۵% of animal bites occurred in rural areas and the remaining in urban areas. The most rabid wolves were from Fars province in southern Iran. The vaccine baits were palatable for the hungry wolves. Seroconversion with antibodies titers ≥۰.۵ IU/ml occurred after ۱۲ weeks and maintained for ۷۸ weeks indicating potential protection against rabies after receiving a single ORV bait. Conclusion: Our results suggested that a single dose of vaccination with V-RG®, though initially designed for foxes and raccoons, can protect the gray wolf against rabies as well.

Keywords:

Oral rabies vaccination (ORV) , Rabies , anti-rabies antibodies , wolf

Authors

Alireza Gholami

National Reference Center for Rabies, Pasteur Institute of Iran, Tehran, Iran

Siamak Massoudi

Department of Environment, Wildlife Diseases Group, Wildlife Bureau, Tehran, Iran

Majid Kharazian Moghaddam

Department of Environment, Iran

Mahmoud Ghazi Marashi

Department of Environment, Wildlife Diseases Group, Wildlife Bureau, Tehran, Iran

Mahyar Marashi

Department of Environment, Wildlife Diseases Group, Wildlife Bureau, Tehran, Iran

Rouzbeh Bashar

National Reference Center for Rabies, Pasteur Institute of Iran, Tehran, Iran

Ahmad Fayaz

National Reference Center for Rabies, Pasteur Institute of Iran, Tehran, Iran

Maryam Fazeli

National Reference Center for Rabies, Pasteur Institute of Iran, Tehran, Iran

Firouzeh Farahtaj

National Reference Center for Rabies, Pasteur Institute of Iran, Tehran, Iran

Nader Howaizi

National Reference Center for Rabies, Pasteur Institute of Iran, Tehran, Iran

Mohammad Reza Shirzadi

Department of Zoonoses, Center for Communicable Disease Control, Ministry of Health and Medical Education, Tehran, Iran

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