Detection of Carbapenemases Emerging in Acinetobacter baumannii Clinical Isolates by Modified Hodge Test

Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JMMI-2-4_008

تاریخ نمایه سازی: 29 بهمن 1402

Abstract:

Introduction: Acinetobacter baumannii, a known causative agent of nosocomial infections, is one of the highly antibiotic-resistant gram-negative bacilli. Carbapenem-resistant Acinetobacter isolates are increasingly reported worldwide. Carbapenems such as imipenem and meropenem are efficient antimicrobial agents commonly used for the treatment of infections caused by multi- resistant A. baumannii strains. Some reports indicate treatment failure due to antibiotic resistant A. baumannii strains. The aim of this study was to determine antibiotic resistance pattern and prevalence carbapenemase production in A. baumannii isolates. Method: A total of ۱۰۰ A. baumannii isolates were identified from clinical specimens by standard chemical tests. The samples were collected from the patients hospitalized in two teaching hospitals of Ahvaz, southwestern of Iran. The susceptibility of isolates to different antibiotics was determined by the disk diffusion method based on Clinical Laboratory Standards Institute (CLSI) direction. The Modified Hodge Test (MHT) was performed for detection of carbapenemase - producing A. baumannii isolates. Results: The isolates showed the highest resistance to ciprofloxacin (۹۸%). The resistance rate to cefotaxime, ceftazidime, and piperacillin was ۹۷%, gentamicin, amikacin, and meropenem ۹۶%, imipenem ۹۵%, cefepime ۹۳%, and tetracycline ۶۰%. Most of the isolates (۹۹%) were sensitive to colistin. Among the۱۰۰ A. baumannii isolates, ۵۳ (۵۳%) were positive for carbapenemase production by MHT. Conclusion: This study emphasizes dissemination of carbapenem resistant A. baumannii strains. Our study also showed that the MHT has an excellent sensitivity for detecting carbapenemase - producing A. baumannii isolates.

Authors

Mojtaba Moosavian

Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Nasim Shams

Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mehrandokht Sirous

Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

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