Madleen Nabil Al-Qusous - Department of Clinical Pharmacy, Faculty of Pharmacy, Mutah University, Al-Karak ۶۱۷۱۰, Jordan.
Wajdi Khalaf Jamil Al Madanat - MedLabs Medical Laboratory, Al-Karak, Jordan.
Rasha Mohamed Hussein - Department of Clinical Pharmacy, Faculty of Pharmacy, Mutah University, Al-Karak ۶۱۷۱۰, Jordan & Department of Biochemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef ۶۲۵۱۴, Egypt.

Background: Obesity is an abnormal fat accumulation that adversely affects human health. Studies reported several vitamin deficiencies in obese patients. The current study investigates the deficiencies of vitamins D, B۶, and B۱۲ among Jordanian adults with hyperlipidemia and demonstrates the association between serum vitamin levels and metabolic and lipid profile parameters. Methods: Sixty male subjects were divided into ۴۰ hyperlipidemic patients (age: ۴۵.۹ yr. ±۱۰.۲) and ۲۰ controls (age: ۴۱.۲ yr. ±۱۰.۷). The blood levels of triglycerides, total cholesterol, high density lipoprotein (HDL)-cholesterol, hemoglobin A۱c, and vitamins D, B۶, and B۱۲ were measured. Results: The hyperlipidemic patients showed significantly increased triglycerides, total cholesterol, non-HDL, cholesterol/HDL ratio, low-density lipoprotein (LDL)- cholesterol levels, and decreased HDL-cholesterol levels compared to the controls. No significant differences were found in the blood levels of vitamin D, vitamin B۶, or vitamin B۱۲ between groups. However, ۵۰% of the hyperlipidemic patients and ۵۴.۵% of the controls exhibited vitamin D deficiency. Only the hyperlipidemic patients exhibited deficiencies of vitamins B۶ and B۱۲ in ۵.۴% and ۳.۳% of cases, respectively. In the controls, vitamin B۱۲ level was inversely associated with total cholesterol, whereas in the hyperlipidemic patients, vitamin B۶ level was inversely correlated with total cholesterol and non-HDL levels. Conclusion: The hyperlipidemic patients exhibited vitamins D, B۶, and B۱۲ deficiencies. Additionally, vitamins B۶ and B۱۲ levels were inversely correlated with total cholesterol and non-HDL levels. Our findings highlight the importance of routine evaluation of vitamin levels in patients with hyperlipidemia.

Cholesterol, Hyperlipidemia, Obesity, Vitamins.