Y. Panahi - Pharmacotherapy Department, School of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
M. Sadeghi Ghahroudi - Atherosclerosis Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
E. Hosseinjani - “Department of Cardiology, School of Medicine” and “Shahid Labbafinezhad Hospital”, Shahid Beheshti University of Medical Sciences, Tehran Iran

Aims: Heart failure reduced ejection fraction (HFrEF) is defined as symptoms, such as shortness of breath and edema with an ejection fraction of less than ۴۰% in echocardiography. Regarding the pathogenesis, the role of inflammation is undeniable. Interleukin ۶ (IL-۶) is one of the pro-inflammatory cytokines that is important in cardiovascular disease and has a critical role in CAD. It is also related to complications caused by heart failure and mortality. Nanocurcumin is a polyphenol extracted from the rhizome of Curcuma longa (turmeric) with better bioavailability. Effects of nanocurcumin on the reduction of IL-۶ and NT-proBNP in hospitalized HFrEF patients with acute decompensation were investigated. Materials & Methods: Sixty patients with HFrEF admitted with acute heart failure were divided into the intervention group with the administration of ۴۰ mg of nanocurcumin twice a day for seven days and the control group (placebo). The levels of electrolytes, creatinine, IL-۶, and NT-proBNP were measured at baseline and after one week. Findings: There was no statistically significant difference in the reduction in IL-۶ and NT-proBNP levels in the intervention and control groups (p>۰.۰۵). Also, there was no significant difference in creatinine and estimated glomerular filtration rate in the two groups (p>۰.۰۵). Conclusion: Nanocurcumin at a dose of ۴۰ mg twice a day for seven days in patients with acute decompensated heart failure did not reduce IL-۶ and NT-proBNP levels.

Heart failure, Curcumin, Cardiovascular Diseases