Mehdi Ebrahimi - Internal Medicine Department, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
Alireza Namazi Shabestari - Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Navid Ahmadi - Student&#۰۳۹;s Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
Rahil Mashhadi - Department of Biology, Khatam University, Tehran, Iran
Seyedeh Fatemeh Hoseini - Department of Cellular and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran
Parisa Zahmatkesh - Department of Genetics, Medical Branch, Islamic Azad University, Tehran, Iran
Leila Zareian Baghdadabad - Department of Biology, Medical Biotechnology Research Center, Yazd University, Yazd, Iran
Alireza Khajavi - Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Gholamreza Mesbah - Department of Pathology, AshianGanoTeb Biopharmaceutical Company, Golestan University of Medical Sciences, Gorgan, Iran
Javad Raouf Sarshoori - Department of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Mahdi Khoshchehreh - Department of Pathology, University of California, Los Angeles, USA
Hassan Homayoun - Department of Electrical and Computer Engineering, University of Kashan, Kashan, Iran
Maryam Noori - Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Ramin Rahimnia - Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Mohammadreza Nikoobakht - Department of Urology, Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran

Introduction: We aimed to evaluate whether Liraglutide can remove the deteriorating impact of a high-fat diet (HF) diet on the genitourinary system.Methods: Fifty-six C۵۷ mice were recruited of which received an HF as the intervention group, and a chow diet (CH) as a control group. After two months the case group was sub-grouped into three groups; ۱: group HF with a daily injection of ۰.۴mg/kg liraglutide (HF+Lir), ۲: CH with a daily injection of ۰.۴mg/kg liraglutide (CH+Lir), and ۳:  HF diet with an infusion of normal saline (HF+NS). After two months, all mice were sacrificed for additional testing.Results: Serological analysis showed no significant difference for lipid profile (P-value>۰.۰۵) and hormones except for PSA in males (P-value=۰.۰۱۹). This significance was seen when comparing CH+Lir and HF+NS to the control group (P-values=۰.۰۱۴ and ۰.۰۲۵, respectively). Liraglutide decreases testosterone in both genders and adiponectin and insulin in males. Total sperm count was decreased, and the difference between the groups was significant (P-value=۰.۰۱۳).Conclusions: Liraglutide cannot recover the deteriorating impact of an HF diet on sperm morphology and motility but can improve the sperm DFI and the total number of sperm.

Liraglutide, Urogenital System, Reproductive system, sperm count