A.A Vahidi - Associate Professor of Pediatrics, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
S Parvaresh - Assistant Professor of Pediatrics, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
M.H Torabinejad - Assistant Professor of Pediatrics, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
A Ahmadi - Professor of Pediatrics, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
R Mohamadi - Resident of Pediatrics, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Background & Aims: Major ( -thalassemia is a chronic and costly disease for health care system. Although regular transfusion reduces the disease complications, it is associated with complications of hemosiderosis. This study was performed to determine ( – thalassemia complications in patients referred to Kerman center for special diseases regardless of their age. Methods: This cross-sectional study was conducted on major (-thalassemia patients referred to Samen-al Hojaj institute in Kerman city during winter ۲۰۰۸ to spring ۲۰۰۹. Those with less than ۸ blood transfusion sessions in year were excluded. The results of Physical examination, history, demographic information and laboratory tests were recorded for each patient.   Results: In whole, ۳۴۰ patients were participated of whom, ۵۴.۴% were females, ۵۱.۷۶% were below ۱۵ years old, ۳۷.۶۴% were between ۱۶-۲۴ years old and ۱۰.۵۸% were older than ۲۵ years old. The prevalence of hypothyroidism was ۳.۵%. There was no case of hypothyroidism in the age group )۱۵ years old. The prevalence of hypoparathyroidism was ۸.۵%. The most common complication was gonad disorder with the highest prevalence (۸۰.۶%) in patients over ۲۵ years old. There was no case of renal or adrenal diseases. The incidence of heart disorders was ۹.۱% and ۲.۳% had hepatic disorder that all were older than ۱۵ years old. The prevalence rates of HBV, HCV, HIV were ۲.۵%, ۳۳% and ۰% respectively. Conclusion: Regarding the direct correlation between age and prevalence of complications, performing routine evaluations especially for those older than ۱۵ years is recommended. Since endocrinopathies and liver and heart diseases are common in adult patients with major ( – thalassemia, early diagnosis and regular physical examinations are necessary for prevention of complications

Beta-thalassemia, Endocrine system diseases, Heart Diseases, Liver diseases, Ferritins, Hemosiderosis