Sh Shahabi - PhD. Student of Immunology
Z.M Hassan - PhD. Student of Immunology
S.M Hashemi - MSc. Student of Immunology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
S Shahrokhi - MSc. Student of Immunology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
M Karimipour - Assistant Professor of Anatomy, Shool of Medicine, Orumie University of Medical Sciences, Orumie, Iran
A Kazem Nejad - Professor of Biostatistics
S.Z Bathaie - Professor of Biostatistics
T Tarihi - Professor of Anatomy, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran

The present study aimed at evaluating the effect of local hyperthermia on the healing of burn wounds. Right and Left flunks of ۸ Balb-c mice (as treated and control wounds respectively) were burned. Local hyperthermia was applied only for the burn wounds of the right flunks (the treated wound). Sampling was accomplished on the ۶th day for half of the mice and on the ۹th day for the other half. The treated wounds had significantly smaller sizes than control wounds on the ۶th day (P=۰.۰۱۹) and the ۹th day (P=۰.۰۰۷). The number of hair follicles and sebaceous glands of the treated wounds were significantly more than those of control wounds both on the ۶th day (P=۰.۰۲۵ & P=۰.۰۴۳, respectively) and on the ۹th day (P=۰.۰۱۲ & P=۰.۰۳۳, respectively). Regarding the neovascularization there was no significant difference between the treated and control wounds on the ۶th day but on the ۹th day the neovascularization of the treated wounds was significantly more comparing to the control wounds (P=۰.۰۲۵). Acute inflammation of the treated wounds was significantly less than the control wounds (P=۰.۰۱۵). Collagen formation and reepithelialization in the treated wounds were more than the control wounds both on the ۶th and ۹th days. It is concluded that local hyperthermia can accelerate the healing process of the second degree burn wounds.

Burn, wound healing, Local hyperthermia