Nasrin Pourghanbar Moghadam - Department of Microbiology, College of Basic Sciences, LahijanBranch, Islamic Azad University, Lahijan, Iran.
Khosro Issazadeh - Department of Microbiology, College of Basic Sciences, LahijanBranch, Islamic Azad University, Lahijan, Iran.
Mirsassan Mirpour - Department of Microbiology, College of Basic Sciences, LahijanBranch, Islamic Azad University, Lahijan, Iran.

Lactic acid bacteria (LAB) are gram positive and non- spore forming bacteria that can produce some special substances for growth inhibition of pathogenic, non-pathogenic and food spoilage bacteria. The aim of this study was to determine the inhibitory effects of Lactobacillus acidophilus PTCC۱۶۴۳ (DSM ۲۰۰۷۹) and Lactobacillus plantarum PTCC ۱۰۵۸ (ATCC ۸۰۱۴) cultural supernatants against urinary tract infections (UTI) agents, including Klebsiella pneumoniae, Enterobacter aerogenes, Escherichia coli and Lactobacilli sppin MRS Broth. Selective culture media and biochemical tests were used for UTI bacteria isolation. Inhibitory effects were evaluated using well diffusion agar and the inhibitory zone diameters were measured after overnight incubation at ۳۵-۳۷°C. The highest inhibitory effect were obtained using L. plantarum PTCC ۱۰۵۸ cultural supernatant against E.coli and the lowest one using L.acidophilus PTCC ۱۶۴۳ cultural supernatant against K.pneumoniae. These Lactobacilli spp.were showed inhibitory effects on all of the isolated bacteria. Totally, L.plantarum PTCC ۱۰۵۸ showed inhibitory activity more than L.acidophilus PTCC ۱۰۵۸. The findings of this study showed that Lactobacilli spp. as a capable candidate for producing antibacterial compounds and using them for treatment and industrial usage.

L.acidophilus PTCC ۱۶۴۳, L. plantarum PTCC ۱۰۵۸, Urinary Tract Infection, probiotics, inhibitory effects