arezoo Manouchehri - Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
khalil pourshamsian - Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran

Heterocycles containing nitrogen element show many medicinal properties. Among them, triazoles show significant anticancer and antifungal properties. Because of the useful properties of these compounds, chemists have always been looking for an easier and more effective way to synthesize these compounds. In this study, ten novel ۳-aminoaryl -۵-aryl-۱,۲,۴-triazoles derivatives were prepared via the reaction of N-acyl-N′-aryl thioureas and hydrazine hydrate in the reflux conditions and characterized by analytical and spectral analyses. In this study, the antibacterial properties of the compounds synthesized by the well diffusion method were investigated. All compounds showed good antibacterial properties against Staphylococcus aureus and Escherichia coli bacteria. Compounds ۳g, ۳f and ۳j had the most antibacterial effect.

Hydrazine, Thioureas derivatives, Triazoles derivatives, Antibacterial, Well Diffusion Method