The role of Herpes Simplex Viruses in triggering type ۲ diabetes

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نوع سند: مقاله ژورنالی
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JR_IJMCM-12-2_007

تاریخ نمایه سازی: 18 اسفند 1402

Abstract:

Recently, some common viruses, like Herpes Simplex Virus ‎‎(HSV), have been ‎‎‎proposed as a risk factor to develop type ۲ diabetes. However, still there is not ‎‎‎enough literature to ‎determine its importance as a triggering or risk factor. This ‎‎‎case-control study is designed to ‎evaluate the Attendance rate of the HSV genome ‎in ‎‎serum samples of diabetic ‎patients.‎ The study and control groups included ‎۵۰‎ ‎serum samples of diabetic type ۲ and ۵۰ non-diabetic respectively. The detecting ‎PCR test for HSV genome types ۱ and ۲ with common DNA polymerase gene ‎region, as the target gene, was optimized. Demographic parameters like ‎Sex, age, ‎and A۱C were ‎recorded too. Amplicon size was ۴۵۴ bp. The specificity and ‎sensitivity ‎of the PCR reaction were۱۰۰% and ۵۰ ‎Copy/reaction respectively. The ‎analysis results showed that neither ‎the genome of HSV-۱ nor ۲ was found in those ‎‎۱۰۰ serum samples. ‎ ‎In ‎addition, there was no relation between sex or A۱C level ‎and HSV genome ‎‎presence. But it seems the relatively young age of this group is ‎effective for obtaining ‎‎these negative results. The small size of this population with ‎negative PCR ‎‎results, clearly shows that HSV infection cannot be a first-order ‎risk ‎factor, but due to time-consuming ‎mechanisms ‎of probable effects, this may affect ‎elderly populations, as obtained results of some studies. ‎Therefore to prevent or ‎manage type ۲ diabetes, still should be more ‎focused on the ‎conventional risk ‎factors such as obesity and malnutrition.‎

Authors

Sanaz Vahabi

Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran

Atousa Ferdousi

Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran

Mohammad Hassan Shahhosseini

Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran