Mohammad Farahbakhsh - Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Laleh Alizadeh - Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zahra Arab-Mazar - Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehrdad Haghighi - Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Simindokht Shoaei - Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Neurobrucellosis (N.B) is a rare and severe form of systemic Brucella infection. We introduced an unusual case that “Psychologic Symptoms” was the most prominent complaints of his family. He was a ۵۰-year-old man who has worked in butchery. His problems had begun ۲ months prior to his admission with mood disorders, arthralgia, weakness, headache, and night sweats; he has recurrent crying with no obvious environmental problem! Wright agglutination test, Coomb’s Wright and ۲ME were negative ۲ times in outpatient work-ups and the other lab tests weren’t useful in diagnosis. Treatment trials for acute sinusitis and aseptic meningitis have had some improvements of symptoms but his clinical condition was not acceptable. A brain MRI was performed; results indicated few T۲W hypersignal points of white matter specially periventricular. Brucellosis serologic tests were requested “for third time” and the results were positive.The patient has treated with cotrimoxazole, doxycycline, and rifampicin for ۶ months. Two weeks after this treatment, all of mentioned symptoms subsided. The brain MRI ۶ weeks after treatment was repeated, and the previously seen lesions had improved. The lumber puncture ۳ months after treatment was repeated and results were normal. Conclusion: It can be concluded that when a patient in an endemic area suffers from chronic mood disorders, headache, fever, and other non-specific manifestations that cannot be explained by other etiologies; it may be a case of NB. In this case, the “repeated” Wright test and excellent response to NB treatment confirmed the diagnosis.

Neurobrucellosis, Headache, Brucella infection, mood disorders, Depression