Fatemeh Golshahi - Assistant Professor, Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Yas Hospital, Tehran, Iran
khoosheh khaleghinezhad - Assistant Professor, Department of Midwifery, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
Behrokh Sahebdel - Assistant Professor, Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Yas Hospital, Tehran, Iran
Nafiseh Saedi - Assistant Professor, Department of Obstetrics and Gynecology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran
Zohreh Salari - Assistant Professor, Fellowship of Maternal- Fetal Medicine, Neishabour University of Medical Sciences, Hakim Hospital, Neishabour, Iran

Amniocentesis is one of the known and accessible methods for prenatal diagnosis, which is performed for various reasons during pregnancy. The present study was performed to determine the most common reasons for amniocentesis to detect aneuploidy. This retrospective cohort study was performed on the records of ۶۳۵ pregnant women who underwent amniocentesis guided by high-resolution ultrasound during ۲۰۱۰-۲۰۱۹ at Yas Hospital of Tehran University of Medical Sciences, Tehran, Iran. The study evaluated the indications for amniocentesis in order to investigate the relationship between each of these indications and fetal aneuploidy results. All participants were evaluated for genetic study results. The prevalence of aneuploidy was ۸.۲% and abnormal screening test was the most common reason for performing amniocentesis (۶۸% of cases). Also, abnormal ultrasound results had the strongest correlation with the possibility of genetic abnormalities in the current pregnancy. Therefore, amniocentesis is highly recommended for women with indications, especially in cases of abnormal ultrasound results.

Amniocentesis, Aneuploidy, Prenatal diagnosis