Maryam Moradi - a) Assistant Professor in Reproductive Health, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran b) Senior Research Fellow, Department of General Practice, School of Public Health and Preventive
Azin Niazi - MSc in Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
Keyvan Abbasi - Doctor of General Medicine, Yasoj University of Medical Sciences, Yasoj, Iran
Sanaz Mollazadeh - PhD Student in Reproductive Health, Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam Nouravaran Feizabadi - MSc of Epidemiology, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Background & aim:. This study systematically reviewed the clinical trials to assesse Achillea millefolium's impact on primary dysmenorrhea and menstrual bleedingMethods: In this systematic review, the databases of Science Direct, PubMed, ProQuest, Cochrane library, Scopus, Web of Science were searched using the keywords of "Dysmenorrhea", "Pain"," Menorrhagia" and "Achilles" until Aug ۲۰۲۲. The study population included women with moderate to severe dysmenorrhea or menorrhagia with a score of ۱۰۰ on Pictorial menstrual bleeding Assessment Chart (PBLAC). Intervention included oral administration of Achillea millefoliums with other modern dosage forms. The Cochran's Risk of Bias tool was applied to evaluate the quality of articles.Results: Among ۸۰ initial articles, six studies were systematically reviewed. Among six reviewed studies, three studies examined the impact of Achillea millefolium on primary dysmenorrhea, two studies evaluated the effect of Achillea millefolium on menorrhagia and one study assessed the impact of Achillea millefolium on both primary dysmenorrhea and menorrhagia. The results showed the effect of Achillea millefolium in pain relief of  dysmenorrhea and reduction of menstrual bleeding.Conclusion: Achillea millefolium is an effective and safe herbal remedy for primary dysmenorrhea and reduction of menstrual bleeding.

Achillea millefolium, Dysmenorrhea, Menorrhagia, Menstrual bleeding, Menstruation, Pain