Francesco Lorusso - Otorhinolaryngology Section, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, AOUP “Paolo Giaccone”, Via del Vespro, ۱۳۳, ۹۰۱۲۷ Palermo, Italy.
Salvatore Di Vincenzo - Otorhinolaryngology Section, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, AOUP “Paolo Giaccone”, Via del Vespro, ۱۳۳, ۹۰۱۲۷ Palermo, Italy.
Valerio Campofiorito - Otorhinolaryngology Section, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, AOUP “Paolo Giaccone”, Via del Vespro, ۱۳۳, ۹۰۱۲۷ Palermo, Italy.
Federico Sireci - Otorhinolaryngology Section, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, AOUP “Paolo Giaccone”, Via del Vespro, ۱۳۳, ۹۰۱۲۷ Palermo, Italy.
Angelo Immordino - Otorhinolaryngology Section, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, AOUP “Paolo Giaccone”, Via del Vespro, ۱۳۳, ۹۰۱۲۷ Palermo, Italy.
Francesco Dispenza - Otorhinolaryngology Section, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, AOUP “Paolo Giaccone”, Via del Vespro, ۱۳۳, ۹۰۱۲۷ Palermo, Italy.

Introduction: Since the introduction of Highly Active Anti-Retroviral Therapy (HAART), there has been a significant increase in the survival of HIV-infected patients. Consequently, there has been increased attention on the potential neoplastic pathologies, such as Kaposi’s sarcoma, associated with AIDS in these individuals. Case Report: In this case report we present, for the first time, a patient affected by Kaposi's sarcoma of the palatine tonsil with a concomitant syphilis infection. The patient underwent enlarged tonsillectomy and continued antiretroviral therapy. There were no signs of disease recurrence at a ۱۲-month follow-up. Conclusions: Despite the rarity of tonsillar localization of Kaposi's sarcoma, it should be suspected in the presence of an HIV-infected patient. Tonsillectomy effectively controls local disease, but comprehensive patient management requires a multidisciplinary team of healthcare professionals, including infectious disease specialists, pathologists, and oncologists who work together to provide high-quality and coordinated care.

HIV, Kaposi’s sarcoma, Tonsillar tumor, Syphilis