Synthesis of new piperazinyl quinolones and investigation of their in vitro antibacterial activities
عنوان مقاله: Synthesis of new piperazinyl quinolones and investigation of their in vitro antibacterial activities
شناسه ملی مقاله: JR_JKMU-5-3_001
منتشر شده در در سال 1376
شناسه ملی مقاله: JR_JKMU-5-3_001
منتشر شده در در سال 1376
مشخصات نویسندگان مقاله:
A.R Foromandi - assistant professor
P Haghighat
S Emami
M.H Moshefi - Assistant professor
خلاصه مقاله:
A.R Foromandi - assistant professor
P Haghighat
S Emami
M.H Moshefi - Assistant professor
Quinolone antibacterial agents are currently used for the treatment of various bacterial infections. The nature of functional group at the ۷ position of the quinolone ring system is known to have strong influence on the spectrum and extent of in vitro antibacterial activity. Accordingly, a series of N-L۲- oxo-۲-(۲- furyl) and N-[۲- oxyimino (۲- furyl) ethyl] piperazinyl quinolone derivatives were synthesized and evaluated for in vitro antibacterial activity. Compounds having ۲- oxo-۲-(-۲ furyl) ethyl group attached to the piperazine ring were as potent as norfloxacin and ciprofloxacin. The oximes were more active than corresponding ketones and original quinolone s against gram positive bacteria but less active against gram negative bacteria. The methyl oximes and O- benzyloximes were almost a potent as the corresponding quinolones against gram positive bacteria but less active against gram negative bacteria.
کلمات کلیدی: Synthesis, quinolones, Antibacterial Activity
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1935007/