Lokesh Gupta - College of Pharmacy, JSS Academy of Techhnical Education, Noida, India ۲۰۱۳۰۱
Arun Mittal - SRM Modinagar College of Pharmacy, SRM-IST, Delhi-NCR Campus, Ghaziabad, India ۲۰۱۲۰۴
Archita Katrolia - College of Pharmacy, JSS Academy of Techhnical Education, Noida, India ۲۰۱۳۰۱
Abhay Raizaday - College of Pharmacy, JSS Academy of Techhnical Education, Noida, India ۲۰۱۳۰۱
Lokesh Kaushik - SRM Modinagar College of Pharmacy, SRM-IST, Delhi-NCR Campus, Ghaziabad, India ۲۰۱۲۰۴
Bishnu Kant Shukla - Department of Civil Engineering, JSS Academy of Technical Education, Noida , India ۲۰۱۳۰۱

Cubosomes are the aqueous dispersions of lipid-based liquid-crystalline bi-continuous phases, with the inner structure comprised of triply periodic, non-intersecting, curved, bilayers folded in cubic symmetry, and are organized to form two disjoined continuous water channels on an infinite periodic minimal surface. This review emphasized the peer findings about history and origin of cubosomes, including preparation, characterization and evaluation techniques, along with its promising features as a bio-therapeutics biodegradable cargo nano-material in descriptive manner. The structures of cubosomes, e.g. Q۲۲۳, Q۲۲۷, Q۲۱۲, Q۲۳۰ etc. are discussed here reflecting their versatile applicability. The automated cubosome preparation method in addition to the general preparation methods and assessment of cubosomes with the aid of both, ordinary visual characterization as well as sophisticated instruments like cryo-TEM, Cryo-FESEM, SAXS, LUMiFuge® have been described. Physical parameter’s quantification approves the drug-carriers system fit in therapeutics, i.e stability analysis, permeation, entrapment efficiency (EE), loading capacity (LC), drug content of dispersions, in-vitro drug release studies, HPLC analysis, in-vivo studies, etc., which are framed here in detail. Cubosomes owes the versatility and desired characteristic of a nanoparticle for drug delivery and other biomedical applications. Therefore, we have described here the up to date wide area applications of cubosomes administered through various routes.

Biodegradable, Cubosome, Drug-delivery, Drug carriers, Nanoparticle