Maryam Kashanian - Department of Obstetrics and Gynecology, Akbarabadi Teaching Hospital, Iran University of Medical Sciences, Tehran, Iran
Nooshin Eshraghi - Department of Obstetrics and Gynecology, Akbarabadi Teaching Hospital, Iran University of Medical Sciences, Tehran, Iran
Majid Kalani - Department of Pediatrics (Neonatology), Akbarabadi Teaching Hospital, Iran University of Medical Science, Tehran, Iran
Arash Bordbar - Department of Pediatrics (Neonatology), Akbarabadi Teaching Hospital, Iran University of Medical Science, Tehran, Iran
Nasim Eshraghi - Department of Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Mahnaz Kalati - Department of Nursing, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran
Sara Norouzi - Department of Obstetrics and Gynecology, Akbarabadi Teaching Hospital, Iran University of Medical Sciences, Tehran, Iran
Amir Hossein Kashanian - Department of Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Background and Objective: Preterm birth is the most important cause of neonatal mortality and morbidity. Finding the best treatment regimen, of antenatal corticosteroids, has been under serious concern. To compare the efficacy of intravascular versus intramuscular betamethasone phosphate on neonatal outcomes in the cases of imminent preterm birth. Method: A double-blind randomized clinical trial was performed on ۱۳۶ eligible pregnant women with gestational age of ۲۶- ۳۴ weeks and imminent preterm birth (delivery within ۲۴ hours). They were randomly assigned into two groups. Group A received intramuscular betamethasone phosphate, and group B received a similar dose of betamethasone phosphate intravenously. Women were followed up to delivery, and their neonatal outcomes were compared. Results: Women of the two groups (۶۸ women in each group), did not show a significant difference in maternal age, BMI, gravidity and parity, gestational age at the time of admission and delivery, history of miscarriage and assisted reproductive techniques, delivery route, sex and weight of newborns, and Apgar score in minutes ۱ and ۵. The need for NICU admission, duration of hospitalization, neonatal respiratory distress syndrome, surfactant requirement, and intubation were lower in the IV betamethasone group. There were no significant differences between the two groups according to necrotizing enterocolitis, intraventricular hemorrhage, and neonatal death. Conclusion: Using IV betamethasone, in cases where there is no enough time to complete the ۲۴-hour betamethasone course due to the possibility of impending delivery, may reduce neonatal complications due to quicker onset of action.

Preterm delivery, betamethasone phosphate, neonatal respiratory distress syndrome, necrotizing enterocolitis, Intraventricular Hemorrhage