The Hemoglobin Levels and Transfusion Intervals of Beta-Thalassemia Patients with Positive and Negative Allo-Autoantibodies
عنوان مقاله: The Hemoglobin Levels and Transfusion Intervals of Beta-Thalassemia Patients with Positive and Negative Allo-Autoantibodies
شناسه ملی مقاله: JR_JMCH-7-5_007
منتشر شده در در سال 1403
شناسه ملی مقاله: JR_JMCH-7-5_007
منتشر شده در در سال 1403
مشخصات نویسندگان مقاله:
Marisa Setiawan - Clinical Pathology Specialization Programme, Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital, Surabaya, Indonesia
Betty Agustina Tambunan - Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital, Surabaya, Indonesia
خلاصه مقاله:
Marisa Setiawan - Clinical Pathology Specialization Programme, Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital, Surabaya, Indonesia
Betty Agustina Tambunan - Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital, Surabaya, Indonesia
Beta-thalassemia is a common cause of anemia. Blood transfusion is the primary therapy for beta-thalassemia patients in Indonesia who are at risk of developing allo-autoantibodies. These antibodies can lead to the lysis of red blood cells, resulting in a rapid decrease in hemoglobin levels and shorter transfusion intervals. This research aims to compare hemoglobin levels and transfusion intervals in beta-thalassemia patients with positive and negative allo-autoantibodies. This research is a retrospective cohort study utilizing medical record data from beta-thalassemia patients who underwent blood transfusions at Dr. Soetomo Hospital. The patients were divided into two groups: those with positive allo-autoantibodies and those with negative allo-autoantibodies. Data on hemoglobin levels and transfusion dates were collected five times consecutively between July and December, ۲۰۲۱. The hemoglobin levels of the two groups were compared using the Mann-Whitney test, while the transfusion intervals were analysed using the T-test. Data were obtained from ۵۲ beta-thalassemia patients who received transfusions, with ۲۵ (۴۸%) testing positive for allo-autoantibodies and ۲۷ (۵۲%) testing negative. It was observed that the hemoglobin levels of the two groups were not significantly different (p = ۰.۷۶۹). Similarly, the transfusion intervals of the two groups were not significantly different (p = ۰.۸۹۹). There were no significant differences in hemoglobin levels and transfusion intervals between patients with positive and negative allo-autoantibodies.
کلمات کلیدی: Anemia Allo, autoantibodies Beta, thalassemia Hemoglobin level Transfusion intervals
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1948432/