Najm majbal abd - Master's student in sports physiology (Department of Sports Physiology, Faculty of EducationalSciences and Psychology, Mohaghegh Ardabili University, Ardabil) (responsible)
FARNAZ SEIFI-ASGSHAHR - Associate Professor of Sports Physiology Department (Sports Physiology Department, Faculty ofEducational Sciences and Psychology, Mohaghegh Ardabili University, Ardabil)

It is a well-known fact that regular exercise and physical activities in general are very important for maintaininghealth and preventing disease. For many years, there was no recommendation for MS patients to participate insports activities. This issue was due to the fact that some patients had reported symptoms of instability duringactivity, followed by an increase in body temperature (Vuori, ۲۰۰۴). But currently, prescribing exercise isconsidered as a useful therapeutic solution to minimize the lack of functional ability in chronic diseases. In manyresearches, it was stated that exercise in MS patients with mild to moderate intensity has similar physical andpsychological benefits to the healthy control group. In recent research, it has been stated that exercise can lead toseveral therapeutic results, such as improving cardio-respiratory function, muscle function, reducing depressionand fatigue and making patients to improve health and quality of life. On the other hand, various researches provedthat sports activity causes many physiological changes in the immune system. Exercise regulates immuneresponses through the production of cytokines, which play a role in regulating the formation of immune andinflammatory responses. In many studies, the effect of short-term exercise on cytokine production in healthypopulation has been examined (Chan et al., ۲۰۱۹). Research has been done on the effect of sports training on thementioned patients. The effect of aerobic activity, resistance training (using body weight) and weight training onwalking ability, strength, fatigue, functional ability, and personal quality of life of people with MS, a review andthe results of each study according to the structure and content of the training program. Selected, differentlyreported (Lorig et al., ۱۹۹۹). Studies have shown that combined aerobic and strength training has an effect on thelevel of IL-۱۷ in women with MS, and after a few weeks of training, the anti-inflammatory effects of exercisehave reduced IL-۱۷ (Golzari et al., ۲۰۱۰). Few researches have been done regarding the effect of exercise oncortisol changes in MS patients.For example, Pyatin۱ and colleagues (۲۰۰۹) used whole body vibration exercises to improve muscle, nerve andflexibility function and presented reports of increasingbone density, decreasing the secretion of anabolic hormones and also decreasing cortisol as a beneficial anti-stresseffect. These researchers concluded that this type of activity is beneficial for people suffering from osteoporosisand obesity (Green et al., ۲۰۲۳).