Fatemeh Amin - Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Najmeh Parvaz - Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Nahid Askari - Department of Biotechnology, Institute of Sciences and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
Morteza Khademalhosseini - Department of Pathology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Sakineh Kahanamani Falahati-pour - Department of Pharmacology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Iman Fatemi - Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
Fatemeh Khajehasani - Department of Radiology, Afzalipour Medicine School, Kerman University of Medical Sciences, Kerman, Iran
Zahra Taghipour - Department of Anatomy, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Soudeh Khanamani Falahati-pour - Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Objective: Pistacia vera is commonly used in traditional medicine to treat various disorders. This study aims to investigate the anti-anemia and hepatoprotective effects of Pistacia vera pericarp extract (PVPE) in a rat model of phenylhydrazine (PHZ)-induced anemia.Materials and Methods: PVPE was prepared using the maceration method. The extract was administered at doses of ۲۰, ۸۰, and ۱۶۰ mg/kg for ۲۸ days to normal and PHZ-treated rats. The effects of PVPE were evaluated in terms of changes in biochemical, histological, hematological, and molecular biomarkers in the liver and blood.Results: Administration of PVPE to the anemic animals significantly restored these deleterious effects on hematological parameters compared to the anemic group. Kupffer cell activation was seen in the liver tissue of the anemic rats. Administration of PVPE mitigated these deleterious effects.Conclusion: PVPE has potent antioxidant activity and may represent a promising treatment for anemia and liver protection in clinical settings.

Anemia, Hepatoprotective, Pistachio, Liver, Antioxidant