Ashok Khanal - Chemistry and Biochemistry Department, University of the Incarnate Word, ۴۳۰۱ Broadway, San Antonio, Texas ۷۸۲۰, United States
Mark McLachlan II - Chemistry and Biochemistry Department, University of the Incarnate Word, ۴۳۰۱ Broadway, San Antonio, Texas ۷۸۲۰, United States
Anthony Castro - Chemistry and Biochemistry Department, University of the Incarnate Word, ۴۳۰۱ Broadway, San Antonio, Texas ۷۸۲۰, United States
Karley Alcala - Chemistry and Biochemistry Department, University of the Incarnate Word, ۴۳۰۱ Broadway, San Antonio, Texas ۷۸۲۰, United States
Natali De La Cerda - Chemistry and Biochemistry Department, University of the Incarnate Word, ۴۳۰۱ Broadway, San Antonio, Texas ۷۸۲۰, United States
Adamina Arias - Chemistry and Biochemistry Department, University of the Incarnate Word, ۴۳۰۱ Broadway, San Antonio, Texas ۷۸۲۰, United States
Abby Miller - Chemistry and Biochemistry Department, University of the Incarnate Word, ۴۳۰۱ Broadway, San Antonio, Texas ۷۸۲۰, United States
Ivanna Montes - Chemistry and Biochemistry Department, University of the Incarnate Word, ۴۳۰۱ Broadway, San Antonio, Texas ۷۸۲۰, United States
Sina Ashraf - Chemistry and Biochemistry Department, University of the Incarnate Word, ۴۳۰۱ Broadway, San Antonio, Texas ۷۸۲۰, United States
Lawrence Tran - School of Osteopathic Medicine, University of the Incarnate Word, ۷۶۱۵ Kennedy Hill Dr, San Antonio, TX ۷۸۲۳۵, United States

Glycols and diols, compounds characterized by the presence of two hydroxyl (-OH) groups, play a pivotal role in numerous chemical and industrial processes owing to their distinctive properties, including water solubility, pharmaceutical applications, antifreeze capabilities, and solvent properties. The principal function of a protecting group lies in temporarily concealing a reactive functional group within a molecule, thereby averting undesirable reactions while allowing other reactions to proceed unhindered. Dimethoxytrityl (DMT) stands out as a commonly employed protecting group in organic synthesis, notably in the realms of oligonucleotide and peptide synthesis. Selective DMT protection of the compounds included in the study were achieved through manipulation of temperature and limiting reagent concentration using cannula transfer in the experiments contributing to the study. The primary hindrance of traditional methodologies for synthesis of mono-DMT-protected compounds lies in the incorporation of high-cost purification of the desired products. This article outlines a chromatography-free methodology for synthesizing mono-DMT-protected derivatives of glycols and diols resulting in high yields and   purity employing economically efficient purification methods such as extraction and precipitation. Characterization is achieved through thin-layer chromatography (TLC) and electrospray ionization mass spectrometry (ESI-MS). Additionally, conducted by undergraduate researchers, this methodology boasts affordability, swiftness, and operational simplicity. Given these merits, it stands as a viable option for inclusion in organic chemistry I and II laboratory projects.

Controlled Synthesis, Chromatography free, Green synthesis, Trityl chemistry, Organic synthesis