The Effects of Olive Leaf Extract Ointment on Third-Degree Burn in Rat

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJVS-17-1_003

تاریخ نمایه سازی: 8 خرداد 1403

Abstract:

Due to the prevalence of burns and the necessity of effective treatment with low and optimal complications, in the present study, the efficacy of olive leaf extract ointment was evaluated as a therapeutic substance for burn wounds. Moreover, the healing effects of olive leaf extract ointment were compared to Silver Sulfadiazine. ۳۶ rats were used in the present study. To create a burn wound, a rectangular piece of copper (۲ x ۱ cm) was put in ۹۴º C water for ۲۰ minutes and then placed on the rats’ skin for ۳۰ seconds. Then, the rats were randomly divided into three groups; ۱) Sham group: Rats did not receive any treatment and just the wound was washed with distilled water. ۲) Control group: In this group rats were treated with silver sulfadiazine. ۳) OLE group: ۱۰% olive leave extract ointment was employed to treat the wounds. Wounds were macroscopically examined during days ۴, ۷, ۱۴, and ۲۱. Histopathological assessments were performed on days ۴, ۷, ۱۴, and ۲۱ in various studied groups. Results revealed that wound contraction was higher in the OLE group compared to the sham and control groups and histopathological examinations indicated that OLE improved wound healing in comparison to the sham group.

Keywords:

Olive Leaf Extract Ointment , Burn , wound healing , Rat

Authors

Abbas Raisi

Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

Ebrahim Sefidbaf

Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

Ghasem Farjanikish

Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

Peyman Esmaeili Fard Barzegar

Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

Mohsen Abbasi

Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

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