Hamid Reza Moslemi - Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.
Amin Nikpasand - Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Azin Tavakoli - Department of Clinical Sciences, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran.
Seyed Mersad Sefidgar - Student of Veterinary Medicine, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.

Objective- Due to its specific position, the canine tooth is more exposed to the injuries, fractures and pulp necrosis. In these cases, the damaged teeth are usually pulled out. The root of this tooth is very large and sometimes extends over the premolar teeth. To extract it, a large amount of alveolar bone tissue should be harvested. Moreover, the cavity remains very large, which results in forming a cavity after repairing. It can be very effective in the form of closure of the mouth and lips.Design- Experimental studyAnimals- five adult male dogs Procedures- In this research, five dogs were selected and their maxillary canine teeth in right and left (۱۰ teeth in total) were surgically removed. Then the right dental cavity was filled with insulin PRF and the left one filled with autograft cancellous bone chips. Three weeks after the surgery, the cavity was sampled for histopathological examination. Factors such as epithelialization rate, fibroplasia, fibrotic reaction and intensity of inflammation were studied. Results- The average score obtained from histological studies implies that epithelialization in PRF group is significantly higher than the other group, and there is no significant difference in other parameters.Conclusion and Clinical Relevance- Since PRF preparation is easy, it is not painful and risky for the patient and does not require any special care after the surgery. Therefore, it is used preferably.

Bone Chip, Canine Tooth, Dog, PRF