D-dimer Level Determination in the Diagnosis of Deep Vein Thrombosis Following Lower Extremity Fracture: a Cross-Sectional Study

Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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تاریخ نمایه سازی: 27 خرداد 1403


Introduction: the determination of D-dimer levels in diagnosing deep vein thrombosis following lower extremity fractures presents a complex yet critical challenge. This cross-sectional study aims to delineate the diagnostic value of D-dimer in this specific patient group, contributing to improved clinical practices and patient outcomes. Material and methods: Blood samples were collected from each participant within ۲۴ hours of hospital admission. D-dimer levels were measured using a quantitative enzyme-linked immunosorbent assay (ELISA) method. The assay was performed in the hospital’s central laboratory following standard operating procedures. The D-dimer levels were expressed in fibrinogen equivalent units (FEU) with a cut-off value of ۵۰۰ ng/mL considered as the threshold for abnormal levels. Results: The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of D-dimer for diagnosing DVT were calculated. Conclusion: the determination of D-dimer levels is a valuable diagnostic tool for detecting DVT in patients with lower extremity fractures. While the high sensitivity and NPV support its use as a preliminary screening test, the moderate specificity and PPV suggest that elevated D-dimer levels should be followed by confirmatory imaging.


Parham Maroufi

Associate Professor of Orthopaedics, Department of Orthopedics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Tala Pourlak

Associate Professor of Pathology, Department of Pathology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran