Inhibition activity of aluminium oxide nanoparticles for herpes simplex type ۱

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_CJES-21-1_011

تاریخ نمایه سازی: 31 خرداد 1403

Abstract:

Several studies have shown that herpes simplex type ۱) HSV-۱ (is one of the viruses resistant to medications, so potential antiherpetic agents need to be evaluated. This study aimed to evaluate the impact of aluminium oxide Nanoparticles (Al۲O۳-NPs) on the HSV-۱ infection. Characterization of Al۲O۳-NPs were performed using field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), dynamic light scattering (DLS), and high-resolution transmission electron microscopy (HRTEM). The MTT test was used to investigate the toxicity action of Al۲O۳-NPs on viable cells. Quantitative Real-Time PCR (qRT-PCR) and TCID۵۰ assays were used to achieve antiherpetic performance of Al۲O۳-NPs. Indirect immunofluorescence assay (IFA) was performed to determine the inhibitory impact of Al۲O۳-NPs on viral antigen expression, and Acyclovir was utilized as a standard agent in all tests. HSV-۱ was subjected to Al۲O۳-NPs at the maximum non-toxic concentration (۱۰۰ μg mL-۱) led to a decrease of ۰.۱, ۰.۷, ۱.۸, and ۲.۵ log۱۰ TCID۵۰ in the infectious titer relative to virus control (P < ۰.۰۰۰۱). This concentration of Al۲O۳-NPs was correlated with ۱۶.۹%, ۴۷.۱ %, ۶۱.۲ %, ۷۲.۵ % and ۷۴.۶ % inhibition rate, calculated on the basis of HSV-۱ viral load compared to virus control. Our results have shown that Al۲O۳-NPs exhibit a robust antiviral activity against HSV-۱. This function demonstrates excellent potential for using Al۲O۳-NP in topical formulations for treating orolabial or genital herpetic lesions.

Authors

Abbas. K. Almansorri

Faculty of Biotechnology, Al-Qasim Green University, Babylon, Iraq

Hider. M. H. Al-Shirifi

Al-Qasim Green University, Environmental Sciences College, Environmental Health Department

Sharafaldin Al-Musawi

College of Food Sciences, Al-Qasim Green University, Babylon Province, Iraq

Bara B Ahmed

Faculty of Biotechnology, Al-Qasim Green University, Babylon, Iraq

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