Gold Nanoparticles in Anti-Aging Interventions: A Comprehensive Exploration of Skin Health and Cosmeceuticals

Publish Year: 1402
نوع سند: مقاله کنفرانسی
زبان: English
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تاریخ نمایه سازی: 1 تیر 1403


The aging population presents a significant challenge in modern society, with an increase in agerelateddiseases due to a longer life expectancy not matched by a similar extension in healthylifespan. This situation demands focused medical research and healthcare advancements in treatingaging-associated conditions. An integrated approach is recommended, encompassing lifestylechanges, diet, and mental and emotional health, to mitigate aging and its related diseases. In skinhealth, innovative nanoparticle-based formulations are being explored to enhance the anti-agingproperties of active ingredients. Skin aging is influenced by intrinsic factors like metabolicslowdown, disease, mitochondrial DNA damage, hormonal changes, and extrinsic factors such asUV radiation, smoking, pollutants, and lifestyle choices. These factors lead to skin issues likedryness, uneven texture, and visible pores. UVB radiation and high blood sugar levels accelerateaging by increasing oxidative stress and collagen damage. Antioxidants are crucial in defendingagainst reactive oxygen species (ROS). Nanoparticles, with sizes under ۱۰۰ nm, include varioustypes like carbon-based, inorganic, organic, and composite nanomaterials. They are used inskincare due to their enhanced skin penetration properties. These nanoparticles, both organic andinorganic, show promise as anti-aging agents, working at different stages of the skin aging process.Understanding the delivery mechanisms of anti-aging agents through the skin is key to creatingeffective anti-aging products. Nanotechnology in cosmeceuticals integrates biologically activeingredients with therapeutic benefits into cosmetics. This technology addresses the limitations oftraditional products by reducing particle size and improving ingredient efficacy.Nanocosmeceuticals are being developed for anti-aging, sun protection, skin lightening, and hairgrowth.Overall, the article highlights the potential of gold nanotechnology in developing effective and safeanti-aging strategies. Further research is warranted to explore the long-term safety and efficacy ofnanoparticle-based formulations for skin rejuvenation and to optimize their delivery for enhancedtherapeutic outcomes.


Azita Saleshi Sichani

MSc. Department of Biotechnology, Faculty of Converging Sciences and Technologies, Islamic Azad University,Science and Research Branch, Tehran, Iran

Samila Farokhimanesh

PhD, Department of Medical Biotechnology, Faculty of Medical Sciences and Technologies, Islamic AzadUniversity, Science and Research Branch, Tehran, Iran