Nadia Najafizade - Department of Radiation Oncology, Isfahan University of Medical Sciences, Isfahan, Iran
Ali Ebrahimi - Department of Radiation Oncology, Isfahan University of Medical Sciences, Isfahan, Iran
Simin Hemati - Department of Radiation Oncology, Isfahan University of Medical Sciences, Isfahan, Iran

Background: Colorectal cancer ranks as the third most prevalent cancer type globally. In addition to surgery, chemotherapy, and radiation therapy, being the foremost efficacious and all-encompassing treatment modalities for cancer, pelvic chemoradiotherapy is known to precipitate adverse effects, notably intestinal inflammation. This study delves into assessing the impact of curcumin on the prophylaxis and amelioration of chemoradiotherapy-induced enterocolitis in colorectal cancer patients. Method: This randomized study encompassed ۴۴ colorectal cancer patients undergoing standard pelvic chemoradiotherapy, allocated to either curcumin treatment (۲۲ patients) or placebo (۲۲ patients) groups. Patients were administered oral curcumin capsules at a daily dosage of ۵۰۰ mg commencing one week before baseline and extending throughout the standard treatment regimen, adhering to the same schedule. Subsequently, patients were subjected to biweekly evaluations encompassing demographics, clinical characteristics, and manifestations of enterocolitis, with statistical analysis employing Mann-Whitney and chi-square tests. A significance threshold of P < ۰.۰۵ was employed in the study for statistical significance. Results: The incidence of complications exhibited no statistically significant disparity between the two cohorts across diverse disease stages. Furthermore, there were no discernible discrepancies in the manifestation of varying grades of intestinal complications between the curcumin-treated and placebo groups. Predominantly, both groups experienced the most pronounced side-effects during the initial two weeks of treatment. Additionally, there was no statistically significant distinction in the prevalence of adverse drug reactions between the two groups, with figures standing at ۳۱% versus ۴۰% (P = ۰.۱۷). Conclusion: Even though ۵۰۰ mg/day of curcumin over a six-week duration did not engender a statistically significant reduction in the adverse effects of chemoradiotherapy, it was well-tolerated and deemed safe in this patient cohort.

Rectal Neoplasms, Curcumin, Enteritis, Radiation Therapy