The Role of ۱H-MRS and [۱۸F]FDG PET/CT in differentiating primary squamous cell carcinoma and metastatic Hodgkin's lymphoma in lung: An experimental pilot study

Introduction: Distinguishing the cellular origin of lung cancer is essential for tailored patient care. This pioneering pilot study explores the synergy of ۱H-Magnetic Resonance Spectroscopy (۱H-MRS) and ۲-[۱۸F] fluoro-۲-deoxy-D-glucose positron emission tomography/computed tomography ([۱۸F]FDG PET/CT) in the differentiation of primary squamous cell carcinoma (SCC) of the lung from Hodgkin's lymphoma (HL) metastases.Methods: Ethically approved, the study enrolled ۲۱ participants with confirmed lung lesions (۱۰ SCC, ۱۱ HL). [۱۸F]FDG PET/CT and ۱H-MRS were conducted, and analyses were performed to assess diagnostic potential.Results: Significant differences in [۱۸F]FDG PET/CT parameters (SUV max BSA, SUV max LBM, and ID%) between SCC and HL were observed. Metabolite concentrations (Cho, Lac, Cr) from ۱H-MRS also exhibited distinctions. Correlations between PET values and metabolite concentrations hinted at links between glucose metabolism and molecular composition. Conclusion: This study presents an innovative approach, integrating ۱H-MRS and [۱۸F]FDG PET/CT to distinguish primary from metastatic lung lesions. The results hold promise for improving non-invasive diagnostic accuracy and guiding targeted therapies. Future research should validate these findings and explore the potential for clinical integration.

Keywords:

Lung cancer differentiation , ۱H-MRS , [۱۸F]FDG PET/CT , Squamous cell carcinoma , Hodgkin's lymphoma