Mustapha Saeed - Department of Human Physiology, Faculty of Basic Medical Sciences, Federal University Dutse, PMB ۷۱۵۶, Jigawa State, Nigeria
Rabiu Magaji - Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University (ABU), ۸۱۰۱۰۷, Zaria, Nigeria
Mohammed Magaji - Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University (ABU), ۸۱۰۱۰۷, Zaria, Nigeria
Ibrahim Gaya - Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University (ABU), ۸۱۰۱۰۷, Zaria, Nigeria
Baraka Umar - Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University (ABU), ۸۱۰۱۰۷, Zaria, Nigeria
Yusuf Yusha'u - Department of Human Physiology, Faculty of Basic Medical Sciences, Ahmadu Bello University (ABU), ۸۱۰۱۰۷, Zaria, Nigeria
Abubakar Daku - Department of Human Physiology, Faculty of Basic Medical Sciences, Federal University Dutse, PMB ۷۱۵۶, Jigawa State, Nigeria
Musa Chiroma - Neucastle University Medicine Malaysia (NuMed), No. ۱, Jalan Serjana ۱, Kota ilmu, ۷۹۲۰۰ Iskandar Puteri (formerly Nusajaya) Johor-Malaysia
Aliyu Jaafar - Department of Human Anatomy, Faculty of Basic Medical Sciences, Ahmadu Bello University (ABU), ۸۱۰۱۰۷, Zaria, Nigeria
Mohamad Mehat - Department of Anatomy, Faculty of Medicine and Health Science, University Putra Malaysia (UPM), Serdang ۴۳۴۰۰, Selangor, Malaysia
Che Norma Mat Taib - Department of Anatomy, Faculty of Medicine and Health Science, University Putra Malaysia (UPM), Serdang ۴۳۴۰۰, Selangor, Malaysia
Mohamad Aris Mohd Moklas - Department of Anatomy, Faculty of Medicine and Health Science, University Putra Malaysia (UPM), Serdang ۴۳۴۰۰, Selangor, Malaysia

Interest in naturally occurring phytochemicals has been on the increase, they are believed to reduce the risk of brain disorders. Hispidulin (HN) is a phenolic flavonoid compound with various pharmacological and biological effects on the central nervous system. It belongs to the flavone class of flavonoids. It can be found in different plant materials, especially fruits and vegetables. The literature used in this review was collected from credible scientific databases including ScienceDirect, Scopus, PubMed, Google Scholar, and Hindawi without time restriction, using relevant keywords, such as HN, brain, central nervous system, flavonoids, and flavones. HN was discovered to possess pro-apoptotic properties, act as an antioxidant, inhibit cytokine production and toll-like receptor ۴ expression, as well as impede nuclear factor kappa beta and mitogen-activated protein kinase B. HN was also found to inhibit lipid peroxidation in vitro and reduce brain edema in mice. These pharmacological potentials suggest that HN is a promising candidate for neuroprotection in CNS disorders like depression and epilepsy. This review provides an update on the scientific literature concerning how these activities could help provide various forms of neuroprotection in the CNS. Additional experimental data on the effects of HN in models of neurological disorders and neuroprotection should be explored further. Based on the current study, HN is a promising candidate for neuroprotection of the CNS.

Brain, CNS, Flavone, Inflammation, Oxidative stress