Robabeh Baharfa - Department of Chemistry, University of Mazandaran
Somayeh Rassi - Department of Chemistry, University of Mazandaran

A simple synthesis of highly functionalized 2,5-diaminofurans based derivatives from 1-(carboxymethyl) isatin via a multi-component reaction is described. The reactive 1:1 intermedi -ate produced from the reaction of isocyanides and dialkyl acetylene – dicarboxylates was trapped at room temperature by 1-(carboxymethyl)isatin derivatives to yield polyfunctionalized furan rings in fairly good yields.

isatin; one-pot; multi-component reaction; isocyanides; furan; dialkyl acetylene- dicarboxylates