Hamid Ahmadian-Moghadam - Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
Ardeshir Akbarabadi - Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran AND Department of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran
Heidar Toolee - Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Mitra Sadat Sadat-Shirazi - Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
Solmaz Khalifeh - Department of Biology, School of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
Mohammad-Reza Zarrindast - Department of Pharmacology, School of Medicine AND Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Saba Niknamfar - Department of Biology, School of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran

Background: Critical analysis of new evidence in medical sciences relies on statistics in terms of correlation.The aim of the present study was to evaluate the correlation coefficients among the behavioral features in theoffspring of morphine-abstinent parent(s).Methods: The offspring of various types of parental morphine-exposure were divided into ۴ groups includingoffspring of healthy parents (CTL), offspring of paternal morphine-abstinence (PMA), offspring of maternalmorphine-abstinence (MMA), and offspring of both morphine-abstinence (BMA). Pain perception,depression-like behavior, and avoidance memory in the offspring were quantified. The logical structure ofassociation was measured using the Pearson correlation analysis.Findings: A strong correlation was observed between pain and depressive-like behavior in female and maleoffspring of healthy parents. Moreover, in the male and female offspring of healthy parents and BMA, nosignificant correlation was observed between avoidance memory and pain behavior or depressive-likebehavior. However, in the offspring of MMA, a strong correlation was observed between avoidance memoryand depressive-like behavior.Conclusion: The results of the study signified the importance of correlation analysis in addictive behavior. Theresults revealed that the pattern of correlation of the behavior of the offspring of MMA and PMA differed

Correlation study, Administration, Epigenetic, Behavior, Morphine