Wafa Badulla - Section of Analytical Chemistry, Faculty of Pharmacy, Aden University, Aden, Yemen
Abdul-Rahman Ben Yahiya - Department of Analytical Chemistry, Faculty of Pharmacy, Aden University, Aden, Yemen

AbstractBackground: Saliva is a biological fluid that has multiple protective functions. These functions can beattained only if the saliva keeps certain physo-chemical properties such as pH.Methods: The main purpose of the current study was to compare the salivary pH among khat chewers andnon-khat chewers before and after specific intervals (۱۵, ۳۰, and ۶۰ minutes) of using three commerciallyavailable mouthwashes (MWs). Thirty pharmacy student volunteers were divided into three groups of ۱۰ forthe three MWs. Each group was then subdivided into ۵ volunteers as khat chewer and non-khat chewer. Thestatistical evaluation was carried out by using paired t-test and analysis of variance (ANOVA) for in vivostudy of salivary pH.Findings: Low salivary pH in all khat-user volunteers before and after using MWs was indicated. There wasan increase in the salivary pH after ۱۵ minutes of rinsing with the three selected MWs for both groups ofvolunteers, after that there was a gradual decrease to the initial pH. The difference between the three groupswas not significant at baseline and after ۱۵ minutes, but there was a significant difference after ۳۰ and ۶۰minutes for the non-khat-chewing and khat-chewing volunteers.Conclusion: It can be concluded that using MWs results in altering salivary pH and continuous khat chewinglowers the baseline pH of saliva and ability to compensate the change of salivary pH.

Mouthwashes, Khat, Saliva