Mohammad Mehdi Hayatbakhsh Abbasi - Associate Professor of Gastroenterology, Department of Gastroenterology, Kerman University of Medical Sciences
Mehdi Ansari - Associate Professor of Pharmaceutics, Pharmaceutics Research Center, Kerman University of Medical Sciences
Armita Shahesmaeili - General Practitioner, Physiology Research Center, Clinical Research Department, Afzalipour Medical Center, Kerman University of Medical Sciences
Ali Qaraie - General Practitioner, Kerman University of Medical Sciences

Abstract Backgrond: Drug abuse, especially opium abuse, is a major public health problem in Iran. Recent reports suggest that opium sellers cheat their customers by adding lead to the opium. Contaminated opium can threaten the health of consumers. The present study aimed to compare the serum level of lead between opium dependents and a control group. Methods: This was a cross-sectional study in which ۵۰ opium dependents aged ۲۰ to ۶۰ years old were compared with a control group of ۴۳ non-dependents who were matched with the case group in terms of sex and age. The serum level of lead and liver function tests including serum total bilirubin, AST, ALT, Alkaline-phosphatase and hemoglobin were measured for all subjects. Findings: The mean level of serum lead concentration in opium dependents and controls was ۳۹۲۹.۳۵۸ ± ۱۴۷.۶۷ and ۳۵۳۲.۷۲۱ ± ۱۱۴۱.۵۳, respectively and the difference was not statistically significant. There was no significant correlation between serum level of lead and age, duration of opium dependency, serum total bilirubin, hemoglobin, AST, ALT, and Alkaline-phosphate. Conclusion: Although there was no significant relationship between opium consumption and serum level of lead, the concentration of lead in dependents' serum was higher than controls. Further studies are needed to approve this relationship to be used for screening and on time diagnosis of opium dependents. Keywords: Opium, Addiction, Lead poisoning, Serum level.