Comparison of Buprenorphine and Buprenorphine/naloxone in Detoxification of Opioid-dependent Men

Background: Buprenorphine sublingual tablets are now available in Iran for opioid detoxification in clinics. Aim of the present study was to compare the efficiency of buprenorphine with buprenorphine/naloxone in short-term detoxification in a group of Iranian male opioid-dependent patients. Methods:A double-blind trial was carried out on a group of male opioid dependent patients in a psychiatric hospital in Kerman, Iran, during year ۲۰۱۷. A group of ۱۰۰ men who met the diagnostic criteria for opiate dependence were included in the study from individuals who had referred for detoxification. They were allocated to the two groups receiving either buprenorphine (n = ۵۱) or buprenorphine/naloxone (n = ۴۹). Severity of withdrawal symptoms and signs were evaluated by Clinical Opiate Withdrawal Scale (COWS) and Adjective Rating Scale for Withdrawal (ARSW). Findings: The mean scores of COWS and ARSW in the two groups treated with buprenorphine and buprenorphine/naloxone significantly reduced from the first day to the fifth day of detoxification (P < ۰.۰۵۰). Moreover, there was no significant difference between the two groups in terms of objective and subjective symptom reduction (P > ۰.۰۵۰). Conclusion: Buprenorphine/naloxone is as effective as buprenorphine in controlling opiate withdrawal symptoms.

Keywords:

Addiction , Detoxification , Buprenorphine , Buprenorphine/naloxone