Shahla Yazdani - Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Mohammad Ranaei - Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Maryam Javadian - Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
Arghavan Ghafari - Student Committee Research, Babol University of Medical Sciences, Babol, Iran
Mina Galeshi - Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
Karimollah Hajian-Taliki - Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Zinatossadat Bouzari - Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Background & Objective: Anemia, thrombocytosis, and leukocytosis, are commonly found in a variety of malignancies. The prognostic role of preoperative leukocytosis, anemia, and thrombocytosis on stages and grades of endometrial cancer (EC) in women undergoing surgery was the subject of this study.Materials & Methods: In this cross-sectional study, ۱۰۵ women suffering from EC at Babol Ayatollah Rouhani Hospital from ۲۰۱۱ to ۲۰۱۸ were considered. Anemia, thrombocytosis, and leukocytosis were defined as prognostic factors. Then, the patients were placed at stages I, II, III, and IV, and ECs were graded as well, moderately and poorly differentiated or undifferentiated.  SPSS ۲۲ software, Chi-square, analysis of variance (ANOVA), and receiver operating characteristic (ROC) were used for statistical analysis (p < ۰.۰۵).Results: Higher rates of leukocytosis (۵۴.۳%), anemia (۴۷.۴%), and thrombocytosis (۶۶.۷%) were detected in tumor grades III, II, and III, respectively. A higher rate of leucocytosis (۵۱.۴%), anemia (۶۰.۵%), and thrombocytosis (۵۱.۹%) were reported in tumor stages III, I, and III, respectively. The relationship between tumor grade and tumor stage with leucocytosis and thrombocytosis was statistically significant (p <۰.۰۰۱). The white blood cell (WBC) sensitivity (۷۰%) and specificity (۷۰%), Hb sensitivity (۳۷%) and specificity (۳۹%), and platelets sensitivity (۷۳%) and specificity (۷۴%) were determined. There was a significant relationship between levels below the ۳-variable curve and tumor stage with WBC (p <۰.۰۰۱) and platelet (p <۰.۰۰۱).Conclusion: Preoperative leukocytosis and thrombocytosis are related to the severity, stages, and grades of EC. Both of them have a prognostic role in women suffering from EC.

Endometrial Cancer, Leukocytosis, Thrombocytosis, Anemia