Evaluation of antioxidant-oxidant status of saliva in recurrent aphthous stomatitis: A systematic review
عنوان مقاله: Evaluation of antioxidant-oxidant status of saliva in recurrent aphthous stomatitis: A systematic review
شناسه ملی مقاله: JR_JOHOE-9-2_001
منتشر شده در در سال 1399
شناسه ملی مقاله: JR_JOHOE-9-2_001
منتشر شده در در سال 1399
مشخصات نویسندگان مقاله:
Paria Motahari - Assistant Professor, Department of Oral Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
خلاصه مقاله:
Paria Motahari - Assistant Professor, Department of Oral Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
BACKGROUND AND AIM: Recurrent aphthous stomatitis (RAS) as a common oral lesion may be created due to oxidative stress. In this study, we intend to examine the salivary antioxidant-oxidant status in patients with RAS. METHODS: In this review study, all English and Persian articles were searched by relevant keywords from the PubMed, ScienceDirect, Cochrane, Scopus and SID databases from ۱۹۹۵ to ۳۰ March ۲۰۲۰. Two independent reviewers performed the study selection using the specified eligibility criteria. Finally, Newcastle-Ottawa Scale (NOS) method was used for the quality evaluation of studies. RESULTS: A systematic search on the references led to the identification of ۸۷ articles, of which ۶۸ were excluded and finally, ۱۹ articles were included in the study. The majority of the studies (۸۶%) showed no significant decrease in the total antioxidant capacity (TAC). In ۷۱% of the studies, the malondialdehyde (MDA) levels exhibited an increasing trend and in all studies, Glutathione peroxidase (GPx) had a decreasing trend; the results in relation to uric acid were contradictory. CONCLUSION: Beyond the need for more extensive research in this area, it can be concluded that since RAS has multifactorial etiology, changes in the body’s antioxidant-oxidant status are considered as an effective factor along with other factors.
کلمات کلیدی: Saliva, Aphthous, stomatitis, Antioxidants, oxidative stress
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/2038757/